My work primarily focuses on the dosimetric challenges we encounter in preclinical ion beam research. A main goal of my project is to develop a streamlined workflow that allows for precise irradiation of small animals with ion beams and to implement the necessary technological prerequisites along that road. This encompasses topics such as dosimetric measurements, beam modelling, treatment planning, computed tomography (CT) imaging, image guidance and finally the evaluation of dosimetric and imaging data. Ultimately, I aim to provide high quality physics, which will help to bridge knowledge gaps in preclinical ion beam research when combined with high quality biology within our PAIR project.